Effects of sodium deficiency on sodium saccharin drinking

Reproductive toxicology. Sodium saccharin.

The Toll-like receptor 4 (TLR4) is a class I transmembrane receptor expressed on the surface of immune system cells. TLR4 is activated by exposure to lipopolysaccharides derived from the outer membrane of Gram negative bacteria and forms part of the innate immune response in mammals. Like other class 1 receptors, TLR4 is activated by ligand induced dimerization, and recent studies suggest that ...

Evidence on the Carcinogenicity of Sodium Saccharin

Effect of Sodium Bicarbonate and Sodium Chloride on Renal and Hematologic Factors in Patients with Glucose-6-phosphate Dehydrogenase Deficiency

Background: Sodium bicarbonate serum therapy is used for compensation bicarbonate lost and increasing blood pH in metabolic acidosis caused by severe anemia in patient with glucose-6-phosphate dehydrogenase (G6PD) deficiency. The aim of present study was comparison the effect of serum therapy using two different serums (serum with bicarbonate and without bicarbonate) on some renal and hematolo...

Histopathological effects of intramuscular metamizole sodium on rat sciatic nerve

Objective(s): We investigated the histopathological effects of metamizole sodium (MS) on the sciatic nerve.  Materials and Methods: This study was performed using 48 adult male Wistar albino rats. Ten groups were constituted with 6 rats in each group. MS injection into the sciatic nerve (group 1), MS injection into the muscle [group 3 (50 mg/kg, 0.4 ml) and group 5 (50 mg/kg, 0.8 ml)], MS injec...

Effect of dose of sodium saccharin on the induction of rat urinary bladder proliferation.

The effect of sodium saccharin fed to male F344 rats at levels of 5.0, 2.5, 1.0, 0.5, and 0.1% of the diet for 10 weeks was evaluated by autoradiography and scanning electron microscopy. A dose response was evident with both techniques. The labeling index was statistically significantly elevated at all doses above 0.1%. As observed by scanning electron microscopy, the number of foci containing ...